Selected publications
Slutsky, I. Linking activity dyshomeostasis and sleep disturbances in Alzheimer disease. Nature Reviews Neuroscience (accepted).
Shoob, S., Buchbinder, N., Shinikamin, O., Gold, O., Baeloha, H., Langberg, T., Zarhin, D., Shapira, I., Braun, G., Habib, N., and Slutsky, I. (2023). Deep brain stimulation of thalamic nucleus reuniens promotes neuronal and cognitive resilience in an Alzheimer’s disease mouse model. Nature Communications 14, 7002. 10.1038/s41467-023-42721-5. [PDF]
Calafate, S., Özturan, G., Thrupp, N., Vanderlinden, J., Santa-Marinha, L., Morais-Ribeiro, R., Ruggiero, A., Bozic, I., Rusterholz, T., Lorente-Echeverría, B., Dias, M., Chen, W. T., Fiers, M., Lu, A., Vlaeminck, I., Creemers, E., Craessaerts, K., Vandenbempt, J., van Boekholdt, L., Poovathingal, S., Davie, K., Thal, D. R., Wierda, K., Oliveira, T. G., Slutsky, I., Adamantidis, A., De Strooper, B., and de Wit, J. (2023). Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease. Nat Neurosci 26, 1021-1031. 10.1038/s41593-023-01325-4. [PDF]
Katsenelson, M., Shapira, I., Abbas, E., Jevdokimenko, K., Styr, B., Ruggiero, A., Aïd, S., Fornasiero, E. F., Holzenberger, M., Rizzoli, S. O., and Slutsky, I. (2022) IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter, Proceedings of the National Academy of Sciences 119, e2121040119. [PDF]
Zarhin, D*, Atsmon, R*, Ruggiero, A, Baeloha, H, Shoob, S, Scharf, O, Heim, LR, Buchbinder, N, Shinikamin, O, Shapira, I, Styr, B., Braun, G., Harel, M., Sheinin, A., Geva, N., Sela, Y., Saito, T., Saido, T., Geiger, T., Nir, Y., Ziv, Y., Slutsky, I. (2022). Disrupted neural correlates of anesthesia and sleep reveal early circuit dysfunctions in Alzheimer models. Cell Reports 38(3) 10.1016/j.celrep.2021.110268. [PDF]
Heim, L.R., Shoob, S., De Marcas, L., Zarhin, D., Slutsky, I. (2022). Measuring synaptic transmission and plasticity with fEPSP recordings in behaving mice. STAR Protocols 3, 101115,1016/j.xpro.2021.101115.
Ruggiero, A*, Katsenelson, M*, Slutsky, I. (2021). Mitochondria: new players in homeostatic regulation of firing rate set points. Trends in Neurosciences, https://doi.org/10.1016/j.tins.2021.03.002 [PDF]
Styr, B*, Gonen, N*, Zarhin, D*, Ruggiero, A, Atsmon, R, Neta Gazit, N, Braun, G, Frere, S, Vertkin, I, Shapira, I, Harel, M, Heim, L, Katsenelson, M, Rechnitz, O, Fadila, S, Derdikman, D, Rubinstein, M, Geiger, T, Ruppin, E, Slutsky, I. (2019) Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility. Neuron, https://doi.org/10.1016/j.neuron.2019.03.045. [PDF] [Preview]
Rice HC, de Malmazet D, Schreurs A, Frere S, Van Molle I, Volkov AN, Creemers E, Vertkin I, Nys J, Ranaivoson FM, Comoletti D, Savas JN, Remaut H, Balschun D, Wierda KD, Slutsky I, Farrow K, De Strooper B, de Wit J (2019). Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission. Science 363, eaao4827. [PDF]
Styr, B. & Slutsky, I. (2018). Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer’s disease. Nature Neuroscience 21(4), 463-473. [PDF] [F1000 recommendation]
Frere, S. & Slutsky, I. (2018). Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse. Neuron 97(1), 32-58. [PDF]
Milshtein-Parush*, H., Frere*, S., Regev, L., Lahav, C., Benbenishty, A., Ben-Eliyahu, S., Goshen, I., and Slutsky, I. (2017). Sensory Deprivation Triggers Synaptic and Intrinsic Plasticity in the Hippocampus. Cerebral Cortex, Apr 12:1-14. doi: 10.1093/cercor/bhx084. [PDF]
Gazit N, Vertkin I, Shapira I, Helm M, Slomowitz E, Sheiba M, Mor Y, Rizzoli S, and Slutsky I (2016). IGF-1 receptor differentially regulates spontaneous and evoked transmission via mitochondria at hippocampal synapses. Neuron 89(3), 583-597. [PDF][Video abstract]
Frere, S & Slutsky, I (2016). Targeting PTEN interactions for Alzheimer’s disease. Nature Neurosci. 19: 416-418. [PDF]
Vertkin I, Styr B, Slomowitz E, Ofir N, Shapira I, Berner D, Fedorova T, Laviv T, Barak-Broner N, Greitzer-Antes D, Gassmann M, Bettler B, Lotan I, Slutsky I. GABAB receptor deficiency causes failure of neuronal homeostasis in hippocampal networks (2015). PNAS, doi: 10.1073/pnas.1424810112. [PDF].
Slomowitz E*, Styr B*, Vertkin I, Milshtein-Parush H, Nelken I, Slutsky M & Slutsky I. Interplay between population firing stability and single neuron dynamics in hippocampal networks (2015) eLife, 10.7554/eLife.04378. [PDF].
Fogel H*, Frere S*, Segev O, Bharill S, Shapira I, Gazit N, O’Malley T, Slomowitz E, Berdichevsky Y, Walsh DM, Isacoff EY, Hirsch JA, Slutsky I (2014) Amyloid-β activates presynaptic APP homodimers to increase release probability at excitatory synapses. Cell Reports 7:1560-1576. [PDF] [Supplementary]
Dolev I*, Fogel H*, Milshtein H, Berdichevsky Y, Lipstein N, Brose N, Gazit N, Slutsky I (2013) Spike bursts increase amyloid-beta 40/42 ratio by inducing a presenilin-1 conformational change. Nature Neurosci. 16: 587-595. [PDF]
Laviv T, Vertkin I, Berdichevsky Y, Fogel H, Riven I, Bettler B, Slesinger PA, Slutsky I (2011) Compartmentalization of the GABAB Receptor Signaling Complex Is Required for Presynaptic Inhibition at Hippocampal Synapses. The Journal of Neuroscience 31: 12523-12532. [PDF]
Laviv T*, Riven I*, Dolev I, Vertkin I, Balana B, Slesinger PA, Slutsky I (2010) Basal GABA Regulates GABA(B)R Conformation and Release Probability at Single Hippocampal Synapses. Neuron 67: 253-267. [PDF]
Highlighted by Nature Reviews Neuroscience 11, 664 (2010). [PDF]
Slutsky I*, Abumaria N*, Wu LJ, Huang C, Zhang L, Li B, Zhao X, Govindarajan A, Zhao MG, Zhuo M, Tonegawa S, Liu G (2010) Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron 65: 165-177. [PDF]
Accompanied by preview in Neuron by A. Bush, 143-114. [PDF]
Abramov E*, Dolev I*, Fogel H, Ciccotosto GD, Ruff E, Slutsky I (2009) Amyloid-[beta] as a positive endogenous regulator of release probability at hippocampal synapses. Nature Neurosci 12: 1567-1576. [PDF]
Slutsky I, Sadeghpour S, Li B, Liu G (2004) Enhancement of synaptic plasticity through chronically reduced Ca2+ flux during uncorrelated activity. Neuron 44: 835-849. [PDF].
Accompanied by preview in Neuron by G. Awatramani and T.H. Murphy, 743-744. [PDF]